The Histologic Evaluation of Atorvastatin and Melatonin Treatment on Oxidative Stress and Apoptosis of Diabetic Rat Pancreas

نویسندگان

  • Tuğba GÜRPINAR
  • Nuran EKERBİÇER
  • Nazan UYSAL
  • Turgay BARUT
  • Figen TARAKÇI
چکیده

[1] The work is supported by grants from Research Foundation of Celal Bayar University (Project No: TIP 2006/47) * Celal Bayar Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, TR-45030 Manisa TURKEY ** Celal Bayar Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, TR-45030 Manisa TURKEY *** Dokuz Eylül Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı Anabilim Dalı, TR-35030 İzmir TURKEY **** Celal Bayar Üniversitesi, Tıp Fakültesi, Histoloji Anabilim Dalı, TR-45030 Manisa TURKEY ***** Celal Bayar Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, TR-45030 Manisa TURKEY

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Biochemical and Histological Study of Protective Effect of Sodium Tungstate on Oxidative Stress Induced by Streptozotocin in Pancreas of Diabetic Rats

Purpose: The aim of this study was evaluation of effects of sodium tungstate on oxidative stress in pancreas of streptozotocin induced diabetic rats. Materials and Methods: Sixty mature Wistar male rats (Age: 2-3 month) were selected and divided into six groups randomly (n=10). Control (C), STZ-induced diabetic (D), STZ-induced diabetic rats were treated by sodium tungstate (1 mg/ml) in drinkin...

متن کامل

Evaluation Effects of Quercetin on Liver Apoptosis in Streptozotocin-induced Diabetic Rat

  Background: Quercetin is a strong antioxidant and long-term treatment of STZ-diabetic animals and it has been shown to reduce oxidative stress.   Objective: Antioxidants have essential effect on spermatogenesis and sperm parameters. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus.   Methods...

متن کامل

Effects of Atorvastatin on the Hypertension-Induced Oxidative Stress in the Rat Brain

Background: It is well known that the development of brain oxidative stress is one of the most serious complications of arterial hypertension that evokes brain tissue damage. The aim of this study was to examine the effects of atorvastatin treatment (20 mg/kg/day), as an antioxidant, to prevent the brain tissue oxidative stress in the hypertensive (HTN) rats. Methods: Experiments were performed...

متن کامل

The Effect of Aerobic Exercise & L-Carnitine Consumption on Diabetes-Induced Apoptosis & Oxidative Stress Factors in Rat

Objective: The use of non-enzymatic antioxidants in the form of dietary supplements has a positive effect on reducing oxidative stress, and preventing apoptosis as they interrupt free radicals. The aim of this study was to investigate the aerobic exercise and L-carnitine consumption impacts on diabetes induced apoptosis, oxidative stress factors, and mitochondrial enzymes in rats. Materials an...

متن کامل

THE EFFECT OF AEROBIC EXERCISE WITH MELATONIN ON RAGE GENE EXPRESSION AND SOME INDICATORS OF OXIDATIVE STRESS IN MALE RATS WITH DIABETIC NEUROPATHIC PAIN

Background: Neuroinflammation and oxidative stress play a pivotal role in the diabetic neuropathic pain. The aim of this study was to evaluate the effect of aerobic exercise with melatonin on RAGE gene expression and some indicators of oxidative stress in rats with diabetic neuropathic pain Methods: Forty 8-week-old male Wistar rats (weight range 204 ± 11.3 g) were randomly divided into five o...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010